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KMID : 0388220140210010004
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Journal of the Korean Rheumatism Association
2014 Volume.21 No. 1 p.4 ~ p.8
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The Systemic Rheumatologic Disease and Neuromyelitis Optica
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Hyun Hye-Sook
Kim Su-Hyun
Kim Ho-Jin
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Abstract
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Neuromyelitis optica (NMO), an autoimmune in-flammatory disease of the central nervous system (CNS), is related with autoantibodies for aquaporin-4, which is the most abundant water channel in CNS. The clinical syndromes of NMO, such as longitudinally extensive trans-verse myelitis and optic neuritis, can occur in the context of systemic rheumatologic diseases, such as systemic lupus erythematosus and Sjogren syndrome. It is debatable as to whether NMO is a feature of genetic tendency toward humoral autoimmunity or a CNS complication of systemic rheumatologic diseases. Current evidence suggests that NMO coexists with systemic rheumatologic diseases rather than a complication from them. Early immunosuppressive therapies should be considered in these patients since just one or two attacks can cause severe neurological disability.
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KEYWORD
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Systemic rheumatologic disease, Neuromyelitis optica, Comorbidity, Complication
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